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Bordone strongly recommends GLP-1s for patients with psoriasis if these conditions apply: A BMI over 30 A BMI over 27 with obstructive sleep apnea High blood pressure Abnormal cholesterol High fasting glucose Insulin resistance Prediabetes Ive seen firsthand how these medications can positively impact patients who have both psoriasis and metabolic conditions like obesity or type 2 diabetes, says Kopelman, who coordinates with her patients primary care providers when she feels a GLP-1 may help